Successful rapid rituximab desensitization in an adolescent patient with nephrotic syndrome: Increase in number of Treg cells after desensitization.
نویسندگان
چکیده
& Immunology (AAAAI)/Food Allergy Initiative, the Gerber Foundation, the Dorothy and Frank Robins Family, the National Peanut Board, the Howard Gittis Memorial 3rd Year/4th Year Fellowship/Instructor Award (to J.A.B.), and the Wallace Research Foundation (grant no. WRF2010.01). Additional support for the project was provided by the National Center for Research Resources (NCRR, grant no. UL1RR024128), a component of the NIH and NIH Roadmap for Medical Research, and its contents are solely the responsibility of the authors and do not necessarily represent the official view of the NCRR or the NIH. Disclosure of potential conflict of interest: A. W. Burks is on the board for the AAAAI, the NIH’s HAI (Human-Animal Interaction) Study Section, the Food Allergy & Anaphylaxis Network, the US Food and Drug Administration’s Food Advisory Committee, the Anaphylaxis Network Research Advisory Board, and the Merck US Allergy Immunotherapy Allergist Advisory Board; has received consultancy fees from ActoGeniX, Curalogic, Dow AgroSciences, McNeill Nutritionals, Merck & Co, Novartis Pharma AG, Sanofi-Aventis US, Schering-Plough, and Unilever; is employed by Duke University Medical Center and UNC Children’s Hospital; has received one or more grants from or has one or more grants pending with the NIH and the Wallace Research Foundation; has received one or more payments for lecturing from or is on the speakers’ bureau for Abbott Laboratories and Mylan Specialty; has one or more patents (planned, pending, or issued) (US5558869, US5973121, US6441142, US6835824, US7485708, US7879977); has received payment for educational presentations development from Current Views 2012; and has stock/stock options in Allertein. S. M. Jones is a Board member for the Food Allergy & Anaphylaxis Network; has received one or more grants from or has one or more grants pending with the NIH, the Food Allergy & Anaphylaxis Network, and the National Peanut Board; has received one or more payments for lecturing from or is on the speakers’ bureau for Abbot Nutrition International, the Kentucky Society for Allergy, Asthma, & Immunology, the New England Allergy Society, the American College of Allergy, Asthma & Immunology, the Indiana University Medical School and Riley Children’s Hospital, the Spanish Society of Allergy & Clinical Immunology, and the Oregon Allergy Asthma & Immunology Society; is a member of the NIAID Safety Monitoring Committee and the Arkansas Medicaid Drug Review Committee, and an NIAID Study Section. E. H. Kim has received one or more consulting fees or honoraria from and has consultancy arrangements with Triangle E Technologies. M. D. Kulis has been supported by one or more grants from the NIH, is employed by Duke University and the University of North Carolina at Chapel Hill, and has received an NRSA Fellowship Award from the NIH. A. M. Scurlock has received one or more grants from or has one or more grants pending with the NIH. P. Varshney has been supported by an NIH T32 Training Grant and has received support for travel from the AAAAI. B. P. Vickery has been supported by one or more grants from the NIH, the AAAAI, the Food Allergy Initiative, the Gerber Foundation, the Dorothy and Frank Robins Family, the Nartional Peanut Board, and the Wallace Research Foundation and has received one or more grants from or has one or more grants pending with the NIH-NAIAD and the Foundation of the American College of Allergy, Asthma, and Immunology. The rest of the authors declare that they have no relevant conflicts of interest.
منابع مشابه
Successful Desensitization Efavirenz in 8 -year-Old HIV-Positive Child
Background & Aims: Allergic reaction is a common side effect of Efavirenz and drug replacement may not be an option to physicians. Here, a successful drug desensitization experiment on an 8-year-old female child over a period of 9 days is reported. Case presentation: The patient was an 8-year old female child with HIV in Kerman, Iran who had been received oral efavirenz together with lamivudine...
متن کاملSuccessful Diflunisal Desensitization in a Transthyretin Amyloidosis Patient with NSAID Allergy: A Case Report
Introduction: Amyloid diseases have been known to be hereditary, including transthyretin (TTR) amyloidosis where subunit protein mutations may occur in genes for TTR leading to the deposition of fibrils (low molecular weight subunits (5 to 25 kD) of proteins) in extracellular tissues. By reducing the formation of TTR amyloid, diflunisal, a nonsteroidal anti-inflammatory drug (NSAID), has shown ...
متن کاملSuccessful Desensitization of a Patient with Rituximab Hypersensitivity
Rituximab is a monoclonal antibody which targets CD20 in B cells that is used for the treatment of CD20 positive oncologic and hematologic malignancies. Rituximab causes hypersensitivity reactions during infusions. The delay of treatment or loss of a highly efficient drug can be prevented by rapid drug desensitization method in patients who are allergic to rituximab. We report a low grade B cel...
متن کاملHypersensitivity reactions to mAbs: 105 desensitizations in 23 patients, from evaluation to treatment.
BACKGROUND Rapid desensitization, a procedure for graded drug administration, allows for the safe readministration of a medication after certain types of hypersensitivity reactions (HSRs) and is indicated in cases in which there are no reasonable therapeutic alternatives. The use of rapid desensitization for HSRs to mAbs has not been validated. OBJECTIVE We sought to describe our experience w...
متن کاملImpact of Desensitization on Antiviral Immunity in HLA-Sensitized Kidney Transplant Recipients
Viral infections represent significant morbidity and mortality factors in kidney transplant recipients, with CMV, EBV, and BKV infections being most common. Desensitization (DES) with IVIg and rituximab with/without plasma exchange followed by kidney transplantation with alemtuzumab induction increased successful transplant rates in HLA-sensitized patients but may represent an increased risk fo...
متن کاملSuccessful Renal Transplantation Across HLA Barrier: Report from India
Organ donors are sometimes found "unsuitable" due to the presence of donor-specific anti-HLA antibodies in the recipient. In recent years, improved desensitization protocols have successfully helped to overcome HLA incompatibility hurdle. We present three cases where optimum desensitization was achieved in patients with the donor-specific anti-HLA antibody (DSA) leading to successful renal tran...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of allergy and clinical immunology
دوره 132 2 شماره
صفحات -
تاریخ انتشار 2013